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dc.contributor.authorAcar, Mustafa B.
dc.contributor.authorAprile, Domenico
dc.contributor.authorAyaz-Guner, Serife
dc.contributor.authorGuner, Huseyin
dc.contributor.authorTez, Coskun
dc.contributor.authorDi Bernardo, Giovanni
dc.contributor.authorPeluso, Gianfranco
dc.contributor.authorOzcan, Servet
dc.contributor.authorGalderisi, Umberto
dc.date.accessioned2022-03-05T08:35:33Z
dc.date.available2022-03-05T08:35:33Z
dc.date.issued2021en_US
dc.identifier.issn1422-0067
dc.identifier.otherPubMed ID33669748
dc.identifier.urihttps //doi.org/10.3390/ijms22042064
dc.identifier.urihttps://hdl.handle.net/20.500.12573/1237
dc.descriptionThis work was supported by Erciyes University Research Project Fund (BAP-FDK-20188555) to S.O. We are grateful to Turkey Council of Higher Education for supporting M. Burak Acar with the CoHE 100/2000 Doctoral Scholarship Project. This work was partially supported by Regione Campania Progetto POR "Sviluppo di nanotecnologie Orientate alla Rigenerazione e Ricostruzione tissutale, Impiantologia e Sensoristica Odontoiatria/oculistica-SORRISO" CUP B23D18000250007 to G.P. and U.G. This was partially supported by Life Science Institute Inc., Tokyo, Japan to U.G. for a Joint Re-search Agreement.en_US
dc.description.abstractMuse cells are adult stem cells that are present in the stroma of several organs and possess an enduring capacity to cope with endogenous and exogenous genotoxic stress. In cell therapy, the peculiar biological properties of Muse cells render them a possible natural alternative to mesenchymal stromal cells (MSCs) or to in vitro-generated pluripotent stem cells (iPSCs). Indeed, some studies have proved that Muse cells can survive in adverse microenvironments, such as those present in damaged/injured tissues. We performed an evaluation of Muse cells' proteome under basic conditions and followed oxidative stress treatment in order to identify ontologies, pathways, and networks that can be related to their enduring stress capacity. We executed the same analysis on iPSCs and MSCs, as a comparison. The Muse cells are enriched in several ontologies and pathways, such as endosomal vacuolar trafficking related to stress response, ubiquitin and proteasome degradation, and reactive oxygen scavenging. In Muse cells, the protein-protein interacting network has two key nodes with a high connectivity degree and betweenness: NFKB and CRKL. The protein NFKB is an almost-ubiquitous transcription factor related to many biological processes and can also have a role in protecting cells from apoptosis during exposure to a variety of stressors. CRKL is an adaptor protein and constitutes an integral part of the stress-activated protein kinase (SAPK) pathway. The identified pathways and networks are all involved in the quality control of cell components and may explain the stress resistance of Muse cells.en_US
dc.description.sponsorshipErciyes University Research Project Fund BAP-FDK-20188555 Turkey Council of Higher Education CoHE 100/2000 Doctoral Scholarship Project Regione Campania Progetto POR "Sviluppo di nanotecnologie Orientate alla Rigenerazione e Ricostruzione tissutale, Impiantologia e Sensoristica Odontoiatria/oculistica-SORRISO" CUP B23D18000250007 Life Science Institute Inc., Tokyo, Japanen_US
dc.language.isoengen_US
dc.publisherMDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDen_US
dc.relation.isversionof10.3390/ijms22042064en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectstem cellsen_US
dc.subjectDNA damageen_US
dc.subjectoxidative stressen_US
dc.subjectmesenchymal stromal cellsen_US
dc.titleWhy Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysisen_US
dc.typearticleen_US
dc.contributor.departmentAGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.authorID0000-0002-1052-0961en_US
dc.contributor.institutionauthorAyaz-Guner, Serife
dc.contributor.institutionauthorGuner, Huseyin
dc.identifier.volumeVolume 22 Issue 4en_US
dc.relation.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US


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