• Yara Örtü Malzemesi Olarak Elektroeğrilmiş PCL/PHBV Membranların Hazırlanması ve Karakterizasyonu 

  İşoğlu, İsmail Alper (Bitlis Eren Üniversitesi, 2019)

  Bu çalışmada, yara örtü malzemesi olarak polikaprolakton (PCL), poli(3-hidroksibütirik asit-ko-3-hidroksivalerikasit) (PHBV) ve ağırlıkça farklı oranlarda (100:0, 50:50, 75:25, 0:100) PCL/PHBV karışımları, farklı ...

• Microfluidic Devices: A New Paradigm in Toxicity Studies 

  Yiğit, Fatma Esra; İçöz, Kutay; Boşgelmez, İpek (Hacettepe Üniversitesi, 2020)

  In recent years, great emphasis has been placed on non-animal toxicological methods (e.g. in vitro models, in silico or −omicsdata) as alternative strategies to reduce animal-testing, in line with the 3R (Replacement, ...

• The therapeutic potential of targeting HDAC6 with Tubastatin A in TFK-1 and EGI-1 cholangiocarcinoma cells 

  Yenigül, Münevver; Gencer Akçok, Emel Başak (SİVAS CUMHURİYET ÜNİVERSİTESİ: Sivas Cumhuriyet University, 2021)

  Cholangiocarcinoma (CCA) is a highly aggressive and invasive malignancy with a poor diagnosis because of the resistance, relapse and limited therapy. Histone deacetylases (HDAC) are a class of enzyme that have important ...

• RNA İkincil Yapılarının Çok Boyutlu Gösterimi ve Pre-Mirna Tespiti Için Uygulamaları 

  Saçar Demirci, Müşerref Duygu; Demirci, Yilmaz Mehmet (TUBİTAK, 2021)

  MikroRNA'lar (miRNA'lar), transkripsiyon sonrası gen ekspresyonu düzenleyicileridir. Bir miRNA yüzlerce haberci RNA'yı (mRNA'lar) hedefleyebildiği gibi, bir mRNA farklı miRNA'lar tarafından hedeflenebilir, üstelik tek ...

• Investigation of Antiviral Potential of Food Carotenoids and Apocarotenoids against RNA-dependent RNA Polymerase of Hepatitis C Virus 

  Özkan, Fidan (Bitlis Eren Üniversitesi, 2022)

  Hepatitis C disease have been a global health threat and affects a significant portion of world population. Hepatitis C have also been a silent health threat for Turkiye, where there are around half million people infected ...

• Evaluating the microbial growth kinetics and artificial gastric digestion survival of a novel Pichia kudriavzevii FOL-04 

  Gümüştop, İsmail; Ortakci, Fatih (TAGEM Journals, 2022)

  Present study aims to explore Pichia kudriavzevii FOL-04 (FOL-04)’s: i) survival against artificial gastric juice (AGJ) and artificial bile juice (ABJ), ii) growth kinetics in shake flask (SF) and fed-batch trials (FBT). ...

• RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans 

  Kaplan, Oktay İsmail (TUBİTAK, 2023)

  Projecting from most cell surfaces, cilia serve as important hubs for sensory and signaling processes and have been linked to a variety of human disorders, including Bardet-Biedl Syndrome (BBS), Meckel-Gruber Syndrome ...

• Thermosensitive pluronic® F127-based in situ gel formulation containing nanoparticles for the sustained delivery of paclitaxel 

  Ünal, Sedat; Çelik Tekeli, Merve; Doğan, Osman; Aktaş, Yeşim (Effect Publishing Agency ( EPA ), 2023)

  Bone metastasis is one of the most encountered complications among cancer patients and majority of cancer types has led to bone metastasis. Paclitaxel (PCX) is an anticancer agent commonly used in cancer treatment. However, ...

• Enkapsüle Edilmiş ve Serbest Formda Probiyotik Lactobacillus acidophilus ATCC 4356 Suşunun Dondurma Depolama Periyodunda Stabilitesinin İncelenmesi 

  Sedefoğlu, Sedat; ORTAKCI,Fatih; SERT,Selahattin (Atatürk Üniversitesi, 2022)

  Bu çalışmada probiyotik Lb. acidophilus ATCC 4356 (ATCC 4356) suşu, ekstrüzyon yöntemi ile aljinat kullanılarak kapsüllenmiştir. Bu enkapsüle ve serbest formdaki ATCC 4356 dondurmaya ilave edilerek −18°C’de 3 ay süre ile ...

• EVALUATION OF THE SENSORY CORRELATION BETWEEN TOUCH SENSITIVITY AND THE CAPACITY TO DISCRIMINATE VISCOSITY 

  Aktar, Tugba; Chen, Jianshe; Ettelaie, Rammile; Holmes, Melvin (WILEY, 2015)

  The capacity to discriminate the viscous nature of food materials is critically important in the sensory evaluation and subsequent perception of food texture and acceptability. It is generally assumed that this capability ...

• Combination of the Simple Additive (SAW) Approach and Mixture Design to Determine Optimum Cocoa Combination of the Hot Chocolate Beverage 

  DOGAN, Mahmut; Aktar, Tugba; Toker, Omer Said; Tatlisu, Nevruz Berna (TAYLOR & FRANCIS INC, 2015)

  Physicochemical (pH, brix, and color), sensory (color, taste, odor, mouthfeeling, consistency, bitter flavor, and general acceptability), and rheological properties of the hot chocolate beverages including different cocoa ...

• Liver fibrosis staging using CT image texture analysis and soft computing 

  Kayaalti, Omer; Aksebzeci, Bekir Hakan; Karahan, Ibrahim Okkes; Deniz, Kemal; Ozturk, Mehmet; Yilmaz, Bulent; Kara, Sadik; Asyali, Musa Hakan (ELSEVIER, 2014)

  Liver biopsy is considered to be the gold standard for analyzing chronic hepatitis and fibrosis; however, it is an invasive and expensive approach, which is also difficult to standardize. Medical imaging techniques such ...

• Polyethylenimine Modified and Non-Modified Polymeric Micelles Used for Nasal Administration of Carvedilol 

  Kahraman, Emine; Karagoz, Ayse; Dinçer, Sevil; Ozsoy, Yildiz (AMER SCIENTIFIC PUBLISHERS, 2015)

  This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylen ...

• RAFT-mediated synthesis of poly(N-(2-hydroxypropyl)methacrylamide-b-4-vinylpyridine) by conventional and microwave heating 

  Ozdemir, Zeynep; Topuzogullari, Murat; İsoglu, Ismail Alper; Dincer, Sevil (SPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATES, 2013)

  We report the synthesis of N-(2-hydroxypropyl)methacrylamide (HPMA) macroCTA and HPMA-b-4-Vinylpyridine block copolymers via reversible addition-fragmentation chain transfer (RAFT) reaction. Polymerization was carried out ...

• NeRNA: A negative data generation framework for machine learning applications of noncoding RNAs 

  Orhan, Mehmet Emin; Demirci, Yilmaz Mehmet; Sacar Demirci, Muserref Duygu (PERGAMON-ELSEVIER SCIENCE, 2023)

  Many supervised machine learning based noncoding RNA (ncRNA) analysis methods have been developed to classify and identify novel sequences. During such analysis, the positive learning datasets usually consist of known ...

• Inhibition of pathologic immunoglobulin E in food allergy by EBF-2 and active compound berberine associated with immunometabolism regulation 

  Yang, Nan; Maskey, Anish R.; Srivastava, Kamal; Kim, Monica; Wang, Zixi; Musa, Ibrahim; Shi, Yanmei; Fidan, Ozkan; Wang, Julie; Dunkin, David; Chung, Danna; Zhan, Jixun; Miao, Mingsan; Sampson, Hugh A; Li, Xiu-Min (FRONTIERS MEDIA SA, 2023)

  IntroductionFood allergy is a significant public health problem with limited treatment options. As Food Allergy Herbal Formula 2 (FAHF-2) showed potential as a food allergy treatment, we further developed a purified version ...

• A Top-Down Approach for Finding Affected Pathway Subnetworks in Type 2 Diabetes 

  Unlu Yazici, Miray; Bakir-Gungor, Burcu (IEEE, 2020)

  Diyabet (Diabetes Mellitus, DM), insülin üreten pankreas beta hücrelerindeki fonksiyon bozukluğu, insülin direnci veya insülinin işlevselliğinin bozulması ile meydana gelen bir tür metabolik bozukluktur. Diyabet vakalarının ...

• TACTILE SENSITIVITY and CAPABILITY OF SOFT-SOLID TEXTURE DISCRIMINATION 

  Aktar, Tugba; Ettelaie, Rammile; Chen, Jianshe; Holmes, Melvin (WILEY, 2015)

  The sensation and perception of food texture is regulated by tactile-dominated mechanisms and therefore, it is believed that one’s capability in discriminating food textural properties could be related to one’s tactile ...

• Characterization of genomic, physiological, and probiotic features Lactiplantibacillus plantarum DY46 strain isolated from traditional lactic acid fermented shalgam beverage 

  Yetiman, Ahmet E.; Keskin, Abdullah; Darendeli, Busra Nur; Kotil, Seyfullah Enes; Ortakci, Fatih; Dogan, Mahmut (ELSEVIER, 2022)

  Lactiplantibacillus plantarum is a significant probiotic where it could be found in ubiquitous niches. In this study, a new Lb. plantarum strain DY46 was isolated from a traditional lactic-acid-fermented beverage called ...

• Differential in vitro anti-leukemic activity of resveratrol combined with serine palmitoyltransferase inhibitor myriocin in FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) carrying AML cells 

  Ersoz, Nur Sebnem; Adan, Aysun (SPRINGER, 2022)

  Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) AML is restricted due to toxicity, drug resistance and relapse eventhough targeted therapies are clinically available. Resveratrol with its ...

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