Başlık için Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu listeleme
Toplam kayıt 72, listelenen: 37-56
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A molecular and biophysical comparison of macromolecular changes in imatinib-sensitive and imatinib-resistant K562 cells exposed to ponatinib
(SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)Chronic myeloid leukemia (CML) is a type of hematological malignancy that is characterized by the generation of Philadelphia chromosome encoding BCR/ABL oncoprotein. Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib, ... -
Molecular mechanisms of drug resistance and its reversal in cancer
(Taylor and Francis, 2016)Chemotherapy is the main strategy for the treatment of cancer. However, the main problem limiting the success of chemotherapy is the development of multidrug resistance. The resistance can be intrinsic or acquired. The ... -
Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption
(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKEY, 2019)Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, ... -
A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells
(GALENOS YAYINCILIK, ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY, 2015)Objective: The aims of this study were to examine the cytotoxic and apoptotic effects of KL-21, a novel plant product (produced by Naturin Natural Products, Izmir, Turkey), on 232B4 chronic lymphocytic leukemia (CLL) cells ... -
A novel signaling pathway that governs tumor metastasis: ceramide regulates direct crosstalk between TGF-beta and sonic hedgehog signaling
(WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ, 2016)A novel signaling pathway that governs tumor metastasis: ceramide regulates direct crosstalk between TGF-beta and sonic hedgehog signaling -
A Novel Signaling Pathway that Governs Tumor Metastasis: Ceramide Regulates Direct Crosstalk Between TGF-beta and Sonic Hedgehog Signaling
(WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ, 2016)A Novel Signaling Pathway that Governs Tumor Metastasis: Ceramide Regulates Direct Crosstalk Between TGF-beta and Sonic Hedgehog Signaling -
Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue
(Impact Journals LLC, 2020)The mesenchymal stromal cells (MSCs) residing within the stromal component of visceral adipose tissue appear to be greatly affected by obesity, with impairment of their functions and presence of senescence. To gain further ... -
The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks
(SAGE PUBLICATIONS LTD1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2016)Fisetin and hesperetin, flavonoids from various plants, have several pharmaceutical activities including antioxidative, anti-inflammatory, and anticancer effects. However, studies elucidating the role and the mechanism(s) ... -
Poly(OEGMA)-b-Poly(4-VP) block copolymer nanocarriers for anticancer agent release
(WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 01.06.2018)Poly(OEGMA)-b-Poly(4-VP) block copolymer nanocarriers for anticancer agent release -
Precision medicine in oncology: Challenges, stakes and new paradigms
(JOHN LIBBEY EUROTEXT LTD, 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE, 2019)Precision medicine in oncology: Challenges, stakes and new paradigms -
Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti-tumour properties
(WILEY Online Library, 2023)Genotoxic injuries converge on senescence-executive program that promotes production of a senescence-specific secretome (SASP). The study of SASP is particularly intriguing, since through it a senescence process, triggered ... -
Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases
(BAISHIDENG PUBLISHING GROUP INC, 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES, 2020)Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles in various diseases such as ulcerative ... -
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells
(FRONTIERS MEDIA SAAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND, 2021)Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics. The senolytics selectively ... -
Proteomic fertility markers in ram sperm
(ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, 2021)Precise estimation of ram fertility is important for sheep farming to sustain reproduction efficiency and profitability of production. There, however, is no conventional method to accurately predict ram fertility. The ... -
Protocol for determining the average speed and frequency of kinesin and dynein-driven intraflagellar transport (IFT) in C. elegans
(Cell Press, 2022)Here, we present a protocol to image a fluorescent-labeled intraflagellar transport (IFT) component in Caenorhabditis elegans with fluorescence microscopy, including steps of sample preparations, in vivo live-cell imaging, ... -
Resveratrolün Ph+ Akut Lenfoblastik Lösemide Terapötik Potansiyeli ve Resveratrol Tarafından Tetiklenen Apoptozda Seramid Metabolizmasının Rolü
(TUBİTAK, 2019)Proje ile resveratrolün, Ph+ ALL hücreleri üzerindeki büyümeyi inhibe edici etkisinin arkasında yatan mekanizmalar, seramid metabolizmasının hedeflenmesi ve BCR-ABL ifadesindeki değişimler ile ilişkilendirilerek ... -
Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted “hsa-miR-2278” as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A
(Kluwer Academic Publishers, 2015)BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to ... -
Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells
(ELSEVIER, 2023)In this study, it was aimed to elucidate the interaction between aryl hydrocarbon receptor (AHR), nuclear factor -kappa B (NF-kB), and cytochrome P4501A1 (CYP1A1) with hepatitis B virus X protein (HBX) in a human liver ... -
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis
(BAISHIDENG PUBLISHING GROUP INC, 8226 REGENCY DR, PLEASANTON, CA 94588 USA, 2019)Cytochromes P450s (CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to ... -
Sex effect on the correlation of immunoglobulin G glycosylation with rheumatoid arthritis disease activity
(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, ATATURK BULVARI NO 221, KAVAKLIDERE, ANKARA, 00000, TURKEY, 2020)Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects females more than males with a presence of autoantibodies. Immunoglobulin G (IgG) produced by adaptive arm has 2 functional domains, Fc and Fab. The ...