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dc.contributor.authorKOÇ, NURAY
dc.date.accessioned2020-07-22T10:44:31Z
dc.date.available2020-07-22T10:44:31Z
dc.date.issued2019en_US
dc.identifier.otherTez No: 606276
dc.identifier.urihttps://hdl.handle.net/20.500.12573/333
dc.description.abstractInnovative and bioactive wound dressings prepared by electrospinning mimicking the native structure of the extracellular matrix (ECM) have gained significant interest as an alternative to conventional wound care applications. In this study, bilayered wound dressing material was produced by sequential electrospinning of quaternized poly(4- vinyl pyridine) (upper layer) on the Centella Asiatica (CA) extract containing electrospun poly(D, L-lactide-co-glycolide) (PLGA)/poly(3-hydroxybutyrate-co-3- hydroxy valerate) (PHBV) blend membrane (lower layer). Scanning electron microscopy (SEM) was utilized to show a uniform and bead-free fiber structure of electrospun membranes. The average diameter of CA extract containing electrospun PLGA/PHBV blend membrane was calculated 0.471±0.11 µm, whereas the average fiber diameter of electrospun poly(Q-VP) membranes was in the range of 0.460±0.057 µm. Chemical, thermal, mechanical properties, and adsorption capacity of electrospun membranes, as well as the cumulative release of CA from the electrospun PLGA/PHBV membrane, were investigated. Viability, adhesion, and attachment of human fibroblast cells on the electrospun membranes on pre-set days were evaluated by the colorimetric CellTiter 96® Aqueous One Solution Cell Proliferation Assay (MTS assay) and SEM. Results revealed that CA loaded bilayered electrospun wound dressing showed promoted attachment and proliferation of fibroblasts. Hence, it can be concluded that CA extract containing bilayered electrospun wound dressing prepared in this study has a promising potential for wound healing applications.en_US
dc.language.isoengen_US
dc.publisherAbdullah Gül Üniversitesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWound dressingen_US
dc.subjectElectrospinningen_US
dc.subjectBilayereden_US
dc.subjectCentella Asiaticaen_US
dc.titleCentella asiatica extract containing bilayered electrospun wound dressingen_US
dc.title.alternativeCentella asiatica ekstraktı içeren çift katmanlı elektro eğrilmiş yara örtüsüen_US
dc.typemasterThesisen_US
dc.contributor.departmentAGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.contributor.institutionauthorKOÇ, NURAY
dc.relation.publicationcategoryTezen_US


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