Ara
Toplam kayıt 31, listelenen: 11-20
Differential in vitro anti-leukemic activity of resveratrol combined with serine palmitoyltransferase inhibitor myriocin in FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) carrying AML cells
(SPRINGER, 2022)
Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) AML is restricted due to toxicity, drug resistance and relapse eventhough targeted therapies are clinically available. Resveratrol with its ...
A Top-Down Approach for Finding Affected Pathway Subnetworks in Type 2 Diabetes
(IEEE, 2020)
Diyabet (Diabetes Mellitus, DM), insülin üreten
pankreas beta hücrelerindeki fonksiyon bozukluğu, insülin direnci
veya insülinin işlevselliğinin bozulması ile meydana gelen bir tür
metabolik bozukluktur. Diyabet vakalarının ...
Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors
(SPRINGER BIRKHAUSER, 2023)
In this study, a total of 13 compounds (5-17) were synthesized starting from oleanolic acid (OA), a natural triterpenoid. Five new compounds (10, 11, 12, 15 and 17), are the main targets of the study, which were synthesized ...
NeRNA: A negative data generation framework for machine learning applications of noncoding RNAs
(PERGAMON-ELSEVIER SCIENCE, 2023)
Many supervised machine learning based noncoding RNA (ncRNA) analysis methods have been developed to
classify and identify novel sequences. During such analysis, the positive learning datasets usually consist of
known ...
Preparation and Characterization of Viburnum Opulus Containing Electrospun Membranes as Antibacterial Wound Dressing
(KOREAN FIBER SOC, 2023)
Herein, we fabricated polycaprolactone/gelatin electrospun membranes possessing different amounts of Viburnum Opulus extract (0, 25, 35, 50%, w/v) as an antibacterial wound dressing. We investigated chemical, morphological, ...
Inhibition of PI3K-AKT-mTOR pathway and modulation of histone deacetylase enzymes reduce the growth of acute myeloid leukemia cells
(HUMANA PRESS INC, 2023)
One of the most widespread forms of blood cancer is known as acute myeloid leukemia (AML) which has an incidence of 80% with poor prognosis. Although there are different treatment methods for AML in clinic, the heterogeneity ...
Alantolactone ameliorates graft versus host disease in mice
(ELSEVIER, 2024)
The anti-inflammatory and immunosuppressive drugs which are used in the treatment of Graft-versus-Host
Disease (GVHD) have limited effects in controlling the severity of the disease. In this study, we aimed to
investigate ...
HER2-Targeted, Degradable Core Cross-Linked Micelles for Specific and Dual pH-Sensitive DOX Release
(WILEY-V C H VERLAG GMBHPOSTFACH 101161, 69451 WEINHEIM, GERMANY, 2021)
Here, a targeted, dual-pH responsive, and stable micelle nanocarrier is designed, which specifically selects an HER2 receptor on breast cancer cells. Intracellularly degradable and stabilized micelles are prepared by core ...
Involvement of Sphingolipid Metabolism Enzymes in Resveratrol-Mediated Cytotoxicity in Philadelphia-Positive Acute Lymphoblastic Leukemia
(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND, 2021)
Targeting the key enzymes of sphingolipid metabolism including serine palmitoyltransferase (SPT), sphingosine kinase (SK) and glucosylceramide synthase (GCS) has a therapeutic importance. However, sphingolipid metabolism-mediated ...
Proteomic fertility markers in ram sperm
(ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, 2021)
Precise estimation of ram fertility is important for sheep farming to sustain reproduction efficiency and profitability of production. There, however, is no conventional method to accurately predict ram fertility. The ...