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Toplam kayıt 22, listelenen: 11-20
THERAPEUTIC POTENTIAL OF RESVERATROL AND THE ROLE OF CERAMIDE METABOLISM IN RESVERATROL-TRIGGERED APOPTOSIS IN FLT3+ ACUTE MYELOID LEUKEMIA
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)
Resveratrol’ün FLT3-ITD+ AML hücreleri üzerindeki büyüme engelleyici etkilerinin altında yatan mekanizmalar, seramid metabolizması hedeflenerek araştırıldı. Resveratrol, SK (sfingosin kinaz) inhibitörü (SKI II), GCS ...
IDENTIFICATION OF SURFACE PROTEOME OF B CELL ACUTE LYMPHOBLASTIC LEUKEMIA CELL LINE
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü / Biyomühendislik Ana Bilim Dalı, 2022)
B-cell acute lymphoblastic leukemia is characterized by over and uncontrolled
expression of B lymphocytes. B-ALL may occur as a result of aberrant cytosolic signal
transduction and molecular abnormalities such as gene ...
Identification of single domain antibodies against SARS-CoV-2 omicron variant via protein-protein docking approaches
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)
Omicron, became the dominant variant in 2022 in terms of spreading rate, has
managed to evade from an immune system of patients due to its unique mutations. Single
domain antibodies (sdAb) which are functionally important ...
Discovering new pathogenic variants by In silico analysis
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)
Inherited diseases are health problems caused by one or more abnormalities in the
genome. It can be caused by changes in a single gene (monogenic) or multiple genes
(polygenic), or by a damage on chromosomes. Genetic ...
Cloning of 32-mer MaSP1 Gene ınto pBbB6c plasmid vector and transformation to Escherichia coli neb 10-beta
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)
The main purpose of my thesis was to clone Masp1 spider silk protein encoding gene from dragline type spider into E.coli NEB 10-beta organism. The recombinant microbial production of spider silk protein and converting it ...
Next generation sequencing of a novel Loigolactobacillus coryniformis FOL-19 isolated from cheese and comparative genomic analysis with other L. coryniformis strains
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)
Loigolactobacillus coryniformis is a member of lactic acid bacteria isolated from various ecological niches. We isolated a novel L. coryniformis strain FOL-19 from artisanal Tulum cheese and performed the whole-genome ...
Influence of 3D bioprinting parameters on printability and mechanical behavior of the PCL scaffolds
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023)
Polycaprolactone (PCL) is a synthetic polymer that exhibits desirable properties such as biodegradability, tolerable mechanical properties, and biocompatibility for a diverse range of tissue engineering applications. In ...
Preparation and characterization of UV crosslinked alginate-based tannic acid-reinforced hydrogels
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023)
Alginate is a commonly used biopolymer in bioprinting applications. However, alginate-based bioinks have some mechanical limitations for printing purposes. Also, existing methacrylation methods are time consuming and have ...
BBSome regulates ARL13B-dependent joint elongation of two distinct cilia in Caenorhabditis elegans
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023)
Cilia or flagella are interchangeably used to refer to the hair-like organelles extending from the cell surface to communicate with environmental signals or triggers. Cilium, the singular form of cilia, and its components ...
THE ROLE OF CERAMIDE METABOLISM IN APOPTOSIS TRIGGERED BY RESVERATROL AND THE THERAPEUTIC POTENTIAL OF RESVERATROL IN PH+ ACUTE LYMPHOBLASTIC LEUKEMIA
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)
The mechanisms underlying the growth inhibitory effect of resveratrol on Ph + ALL cells were investigated with regard to targeting of ceramide metabolism and changes in BCR-ABL expression. Growth inhibition and apoptotic ...