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dc.contributor.authorIplik, Elif
dc.contributor.authorErtugrul, Baris
dc.contributor.authorKozanoglu, İlknur
dc.contributor.authorBaran, Yusuf
dc.contributor.authorCakmakoglu, Bedia
dc.date.accessioned2019-06-27T08:41:00Z
dc.date.available2019-06-27T08:41:00Z
dc.date.issued2018en_US
dc.identifier.citationIRANIAN JOURNAL OF BASIC MEDICAL SCIENCES Volume: 21 Issue: 5 Pages: 465-468 DOI: 10.22038/IJBMS.2018.26152.6420en_US
dc.identifier.issn2008-3866
dc.identifier.issne-2008-3874
dc.identifier.otherPubMed ID: 29922425
dc.identifier.otherAccession Number: WOS:000433360100004
dc.identifier.urihttp://acikerisim.agu.edu.tr/xmlui/handle/20.500.12573/42
dc.description.abstractObjective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a therapeutic candidate for conventional disease including cancer. In this research, we have focused on apoptotic effects of adipose tissue-derived MSCs in colon cancer. Materials and Methods: MSCs were obtained from adipose tissue and characterized by Flowcytometer using suitable antibodies. MSCs, HT-29, HCT-116, RKO and healthy cell line MRC5 were cultured by different seeding procedure. After cell viability assay, changes in caspase 3 enzyme activity and the level of phosphatidylserine were measured. Results: For cell viability assay, a 48 hr incubation period was chosen to seed all cells together. There was a 1.36-fold decrease in caspase 3 enzyme activity by co-treatment of RKO and MSCs in addition to 2.02-fold decrease in HT-29 and MSCs co-treatment, and 1.103-fold increase in HCT-116 and MSCs. The results demonstrated that HCT-116 led to the highest rate of apoptotic cell death (7.5%) compared with other cells. Conclusion: We suggest that MSCs might remain a new treatment option for cancer by its differentiation and repair capacity.en_US
dc.description.sponsorshipIstanbul University Scientific Research Project - 39247
dc.language.isoengen_US
dc.publisherMASHHAD UNIV MED SCIENCES, VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 - 445, MASHHAD, 00000, IRANen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectColon canceren_US
dc.subjectStem cellsen_US
dc.subjectCell deathen_US
dc.titleAn answer to colon cancer treatment by mesenchymal stem cell originated from adipose tissueen_US
dc.typearticleen_US
dc.contributor.departmentAGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.institutionauthor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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