Browsing Biyomühendislik Ana Bilim Dalı Tez Koleksiyonu by Issue Date
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Immunomagnetic separation and immobilization of leukemia cells using cell surface markers /
(Abdullah Gül Üniversitesi, 2017)Acute Lympoblastic Leukemia, shortly ALL, especially B-precursor Acute Lymphoblastic Leukemia is the most common blood malignancies among childhood cancers. There are different kinds of leukemia treatments but after those ... -
Centella asiatica extract containing bilayered electrospun wound dressing
(Abdullah Gül Üniversitesi, 2019)Innovative and bioactive wound dressings prepared by electrospinning mimicking the native structure of the extracellular matrix (ECM) have gained significant interest as an alternative to conventional wound care applications. ... -
The effect of hedgehog inhibition and autophagy modulation on the proliferation and survival of AML cell lines /
(2019)Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy which occurs as a result of many chromosomal abnormalities such as translocations, deletions or insertions. Aberrant signaling pathways such as ... -
The inhibition of autophagy and hedgehog pathway leads to a decrease in the proliferation of cholangiocarcinoma
(Abdullah Gül Üniversitesi, 2019)Cholangiocarcinoma (CCA) is the second most common liver cancer type. The median survival rate of CCA patients is really low. Aberrant signaling pathways such as PI3K/AKT/mTOR pathway could be main drivers in CCA pathogenesis. ... -
A BIOMIMETIC APPROACH FOR SMALL DIAMETER VESSELS: BILAYERED VASCULAR GRAFTS MADE of ALGINATE and POLY(-CAPROLACTONE)
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)Cardiovascular diseases (CVDs) still remain one of the leading causes of morbidity and mortality across the world. A typical symptom of CVDs is the vascular occlusion. There are many strategies for treatment such as ... -
DEVELOPMENT OF A KIDNEY TARGETTED NANOCARRIER FORMULATION AGAINST CISPLATIN INDUCED NEPHROTOXICITY
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)Chitosan is a natural polymer which is less toxic in the body than other synthetic polymers. Chitosan sodium tripolyphosphate (TPP) nanoparticles produced by ionic gelation method are known to be good drug delivery agents ... -
THE ROLE OF CERAMIDE METABOLISM IN APOPTOSIS TRIGGERED BY RESVERATROL AND THE THERAPEUTIC POTENTIAL OF RESVERATROL IN PH+ ACUTE LYMPHOBLASTIC LEUKEMIA
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2019)The mechanisms underlying the growth inhibitory effect of resveratrol on Ph + ALL cells were investigated with regard to targeting of ceramide metabolism and changes in BCR-ABL expression. Growth inhibition and apoptotic ... -
CHARACTERIZATION OF NOVEL CILIARY GENE TMEM145
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020)Cilia and flagella are highly conserved, microtubule based cellular structures which are found in most of the organisms. They have variety of functions from enabling movement in protozoa to signal transduction in multi ... -
DEVELOPMENT OF A LOW-COST MICROFLUIDIC SYSTEM TO DETECT IMMUNOMAGNETICALLY CAPTURED LEUKEMIA CELLS
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020)Sensör teknolojileri fiziksel özellikleri ölçülebilir sinyallere dönüştürmek için kullanılır. Özellikle yarı iletken teknolojisindeki gelişmelerle birlikte, mikroakışkan olarak bilinen yeni bir teknoloji ortaya çıktı. ... -
INVESTIGATION OF NEW CILIOPATHY GENES
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)Kirpikler, iç yapısında mikrotübüllerden oluşur ve evrimsel olarak anten benzeri bir organel korunmuştur. Kirpik yapısındaki bozuklukların neden olduğu hastalığa siliyopati adı verilir ve Joubert sendromu siliyopatilerden ... -
THE EFFECT OF HISTONE DEACETYLASE INHIBITORS ON PTEN/PI3K/AKT/mTOR PATHWAY AND THE CARCINOGENESIS OF CHEMORESISTANT CHOLANGIOCARCINOMA AT A MOLECULAR LEVEL
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)Kolanjiokarsinom (CCA) agresif bir adenokarsinomdur ve ikinci en sık görülen birincil karaciğer tümörüdür. CCA gelişiminin kesin etiyolojisi hala net olarak tanımlanmamıştır. Mevcut kemoterapötik tedaviler, çoklu ilaç ... -
THERAPEUTIC POTENTIAL OF RESVERATROL AND THE ROLE OF CERAMIDE METABOLISM IN RESVERATROL-TRIGGERED APOPTOSIS IN FLT3+ ACUTE MYELOID LEUKEMIA
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021)Resveratrol’ün FLT3-ITD+ AML hücreleri üzerindeki büyüme engelleyici etkilerinin altında yatan mekanizmalar, seramid metabolizması hedeflenerek araştırıldı. Resveratrol, SK (sfingosin kinaz) inhibitörü (SKI II), GCS ... -
IDENTIFICATION OF SURFACE PROTEOME OF B CELL ACUTE LYMPHOBLASTIC LEUKEMIA CELL LINE
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü / Biyomühendislik Ana Bilim Dalı, 2022)B-cell acute lymphoblastic leukemia is characterized by over and uncontrolled expression of B lymphocytes. B-ALL may occur as a result of aberrant cytosolic signal transduction and molecular abnormalities such as gene ... -
Identification of single domain antibodies against SARS-CoV-2 omicron variant via protein-protein docking approaches
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Omicron, became the dominant variant in 2022 in terms of spreading rate, has managed to evade from an immune system of patients due to its unique mutations. Single domain antibodies (sdAb) which are functionally important ... -
Discovering new pathogenic variants by In silico analysis
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Inherited diseases are health problems caused by one or more abnormalities in the genome. It can be caused by changes in a single gene (monogenic) or multiple genes (polygenic), or by a damage on chromosomes. Genetic ... -
The effect of histone deacetylase inhibition and autophagy modulation on the cholangiocarcinoma cells
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022)Cholangiocarcinoma (CCA), also known as biliary tract cancer, is a heterogeneous group of malignancies formed by the differentiation of epithelial cells in the biliary tract. CCA is the second most common primary liver ... -
Cloning of 32-mer MaSP1 Gene ınto pBbB6c plasmid vector and transformation to Escherichia coli neb 10-beta
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)The main purpose of my thesis was to clone Masp1 spider silk protein encoding gene from dragline type spider into E.coli NEB 10-beta organism. The recombinant microbial production of spider silk protein and converting it ... -
Development of breast cancer targeted, multifunctional cross-linked micelle nanocarriers
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)In this thesis, we developed two different micelle-based nanocarriers, which are pH-responsive and core cross-linked micelle (CCMs), and specifically target HER2 receptor on breast cancer cells. Intracellularly degradable ... -
Next generation sequencing of a novel Loigolactobacillus coryniformis FOL-19 isolated from cheese and comparative genomic analysis with other L. coryniformis strains
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023)Loigolactobacillus coryniformis is a member of lactic acid bacteria isolated from various ecological niches. We isolated a novel L. coryniformis strain FOL-19 from artisanal Tulum cheese and performed the whole-genome ... -
Influence of 3D bioprinting parameters on printability and mechanical behavior of the PCL scaffolds
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023)Polycaprolactone (PCL) is a synthetic polymer that exhibits desirable properties such as biodegradability, tolerable mechanical properties, and biocompatibility for a diverse range of tissue engineering applications. In ...
