Engineered Production of Bioactive Natural Products from Medicinal Plants
Özet
Plant natural products have been particularly important due to their use in food, cosmetic, and pharmaceutical industries. In particular,
Traditional Chinese Medicine provides a precious potential for the discovery of bioactive natural products and development of novel modern
medicines. However, the existing production methods for plant natural products such as chemical synthesis and plant extraction does not meet
the current demand. Due to their environmental and economic concerns, engineered production of valuable natural products in microbial hosts
has become an attractive alternative platform. This review covers the recent advances in the engineered production of plant natural products
in microorganisms. A special focus was placed on the biotechnological production of plant‑derived terpenoids, flavonoids, and alkaloids.
Some successful examples of engineered production of plant natural products (or their precursors) such as artemisinin, paclitaxel, naringenin,
quercetin, berberine, and noscapine are summarized. This clearly indicates that the engineered production method is a promising approach
with various advantages over current methods.
