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Alzheimer Disease Associated Loci: APOE Single Nucleotide Polymorphisms in Marmara Region
(MDPI, 2024)Alzheimer’s disease (AD) is a major global health challenge, especially among individuals aged 65 or older. According to population health studies, Turkey has the highest AD prevalence in the Middle East and Europe. To ... -
Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors
(SPRINGER LINK, 2024)The internal tandem duplication (ITD) mutation of the FMS-like receptor tyrosine kinase 3 (FLT3-ITD) is the most common mutation observed in approximately 30% of acute myeloid leukemia (AML) patients. It represents poor ... -
Draft genome of carotenoid-producing endophytic Pseudomonas sp. 102515 from Taxus chinensis
(American Society for Microbiology, 2024)Here, we report the draft genome sequence of endophytic Pseudomonas sp. 102515 isolated from Taxus chinensis collected from Logan, UT, USA. The genome is composed of 36 contigs and around 4.9 Mbp in size. The GC content ... -
Sustainable next-generation color converters from P. harmala seed extracts for solid-state lighting
(Royal Society of Chemistry, 2024)Traditional solid-state lighting heavily relies on color converters, which often have a significant environmental footprint. As an alternative, natural materials such as plant extracts could be employed if their low quantum ... -
High carbohydrate diet decreases microbial diversity and increases IL-1β levels in mice colon
(The Korean Society of Food Science and Technology, 2024)Western diet is known to contribute to intestinal dysbiosis and the progression of inflammation. Although the Turkish diet has different macronutrient contents, the intestinal inflammatory disease incidences in Türkiye are ... -
Elucidating the complex membrane binding of a protein with multiple anchoring domains using extHMMM
(Public Library of Science, 2024)Membrane binding is a crucial mechanism for many proteins, but understanding the specific interactions between proteins and membranes remains a challenging endeavor. Coagulation factor Va (FVa) is a large protein whose ... -
Building a challenging medical dataset for comparative evaluation of classifier capabilities
(ELSEVIER, 2024)Since the 2000s, digitalization has been a crucial transformation in our lives. Nevertheless, digitalization brings a bulk of unstructured textual data to be processed, including articles, clinical records, web pages, and ... -
CilioGenics: an integrated method and database for predicting novel ciliary genes
(Oxford University Press, 2024)Uncovering the full list of human ciliary genes holds enormous promise for the diagnosis of cilia-related human diseases, collectively known as ciliopathies. Currently, genetic diagnoses of many ciliopathies remain incomplete ... -
The Impact of COVID-19 on Healthcare Utilization in Turkey
(ELSEVIER, 2024)Objectives: This study investigates the impact of the COVID-19 pandemic on healthcare utilization in Turkey. Methods: We utilized individual-level data derived from Turkish Statistical Institute's annual surveys between ... -
MoO3/WO3/rGO as electrode material for supercapacitor and catalyst for methanol and ethanol electrooxidation
(Nature Research, 2024)The potential of metal oxides in electrochemical energy storage encouraged our research team to synthesize molybdenum oxide/tungsten oxide nanocomposites (MoO3/WO3) and their hybrid with reduced graphene oxide (rGO), in ... -
Computational Detection of Pre-microRNAs
(Humana Press Inc., 2022)MicroRNA (miRNA) studies have been one of the most popular research areas in recent years. Although thousands of miRNAs have been detected in several species, the majority remains unidentified. Thus, finding novel miRNAs ... -
Thermochemistry of alkali metal cation interactions with histidine: Influence of the side chain
(American Chemical Society, 2012)The interactions of alkali metal cations (M+ = Na+ , K+ , Rb+ , Cs+ ) with the amino acid histidine (His) are examined in detail. Experimentally, bond energies are determined using threshold collision-induced ... -
Activation of methane by Os+: Guided-ion-beam and theoretical studies
(CHEMM, 2013)Activation of methane by the third-row transition-metal cation Os + is studied experimentally by examining the kinetic energy dependence of reactions of Os+ with CH4 and CD4 using guided-ion-beam tandem mass spectrometry. ... -
Air-stable, nanostructured electronic and plasmonic materials from solution-processable, silver nanocrystal building blocks
(American Chemical Society, 2014)Herein we describe a room-temperature, chemical process to transform silver nanocrystal solids, deposited from colloidal solutions, into highly conductive, corrosion-resistant, optical and electronic materials with ... -
Highly flexible, electrically driven, top-emitting, quantum dot light-emitting stickers
(American Chemical Society, 2014)Flexible information displays are key elements in future optoelectronic devices. Quantum dot light-emitting diodes (QLEDs) with advantages in color quality, stability, and cost-effectiveness are emerging as a candidate for ... -
Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents
(American Society of Mechanical Engineers (ASME), 2014)The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin ... -
MSABrowser: dynamic and fast visualization of sequence alignments, variations and annotations
(Oxford University Press, 2021)Sequence alignment is an excellent way to visualize the similarities and differences between DNA, RNA or protein sequences, yet it is currently difficult to jointly view sequence alignment data with genetic variations, ... -
Therapeutic Targeting of FLT3 in Acute Myeloid Leukemia: Current Status and Novel Approaches
(Dove Medical Press Ltd, 2022)FMS-like tyrosine kinase 3 (FLT3) is mutated in approximately 30% of acute myeloid leukemia (AML) patients. The presence of FLT3-ITD (internal tandem duplication, 20–25%) mutation and, to a lesser extent, FLT3-TKD (tyrosine ... -
Cerium Oxide Nanoparticles Biosynthesized Using Fresh Green Walnut Shell in Microwave Environment and their Anticancer Effect on Breast Cancer Cells
(John Wiley and Sons Inc, 2022)In this study, cerium oxide nanoparticles (CONPs) were synthesized using fresh green walnut shell extract in microwave environment. The morphology and structure of the CONPs were determined using ultraviolet-visible (UV/VIS), ... -
The influence of cement kiln dust on strength and durability properties of cement-based systems
(SPRINGER, 2022)There are very few studies in the literature on the usage of CKD in cementitious systems. This article presents the laboratory study results on the infuence of cement kiln dust (CKD) on the properties of mortar made with ...