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dc.contributor.authorİşoğlu, İsmail Alper
dc.contributor.authorBölgen, Nimet
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorVargel, İbrahim
dc.contributor.authorÇelik, Hakan Hamdi
dc.contributor.authorKılıç, Emine
dc.contributor.authorGüzel, Elif
dc.contributor.authorÇavuşoğlu, Tarık
dc.contributor.authorUçkan, Duygu
dc.contributor.authorPişkin, Erhan
dc.date.accessioned2019-06-25T08:11:25Z
dc.date.available2019-06-25T08:11:25Z
dc.date.issued2019en_US
dc.identifier.issn2169-1401
dc.identifier.otherDOI: 10.1080/21691401.2019.1593850
dc.identifier.urihttp://acikerisim.agu.edu.tr/xmlui/handle/20.500.12573/27
dc.description.abstractRepair of cranial bone defects is an important problem in the clinical area. The use of scaffolds combined with stem cells has become a focus in the reconstruction of critical-sized bone defects. Electrospinning became a very attracting method in the preparation of tissue engineering scaffolds in the last decade, due to the unique nanofibrous structure of the electrospun matrices. However, they have a limitation for three dimensional (3D) applications, due to their two-dimensional structure and pore size which is smaller than a cellular diameter which cannot allow cell migration within the structure. In this study, electrospun poly(e-caprolactone) (PCL) membranes were spirally wounded to prepare 3D matrices composed of nanofibers and macrochannels. Mesenchymal stromal/stem cells were injected inside the scaffolds after the constructs were implanted in the cranial bone defects in rats. New bone formation, vascularisation and intramembranous ossification of the critical size calvarial defect were accelerated by using mesenchymal stem cells combined 3D spiral-wounded electrospun matrices.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Groupen_US
dc.relation.ispartofseriesARTIFICIAL CELLS, NANOMEDICINE, AND BIOTECHNOLOGY;VOL. 47, NO. 1, 1094–1100
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone regenerationen_US
dc.subjectcranial defectsen_US
dc.subjectmesenchymal stem cellsen_US
dc.subjectelectrospinningen_US
dc.subjectscaffolden_US
dc.titleStem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bonesen_US
dc.typearticleen_US
dc.contributor.departmentAGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.contributor.institutionauthor
dc.identifier.doi10.1080/21691401.2019.1593850
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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